Effect of adenosine triphosphate on left atrial electrogram interval and dominant frequency in human atrial fibrillation

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Effect of adenosine triphosphate on left atrial electrogram interval and dominant frequency in human atrial fibrillation.

BACKGROUND Complex fractionated atrial electrograms (CFAEs) and high dominant frequency (DF) are targets for atrial fibrillation (AF) ablation. Although adenosine triphosphate (ATP) is known to promote AF by shortening the atrial refractory period, its role in the pathogenesis of CFAEs and DF during AF is not fully understood. METHODS We recorded electrical activity from a 64-electrode basket...

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Evaluation of the characteristics of rotational activation at high-dominant frequency and complex fractionated atrial electrogram sites during atrial fibrillation

BACKGROUND High-dominant frequency (DF) and continuous complex fractionated atrial electrogram (CFAE) sites as surrogates for localized sources maintaining atrial fibrillation (AF) are potential AF ablation targets. This study aimed to evaluate the characteristics of a rotational activation at high-DF and continuous CFAE sites in AF patients. METHODS Thirty-two consecutive AF patients (5 paro...

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Impact of Catheter Contact Force on Human Left Atrial Electrogram Characteristics in Sinus Rhythm and Atrial Fibrillation.

BACKGROUND During left atrial mapping, optimal contact parameters minimizing variation secondary to catheter contact are not established. METHODS AND RESULTS Across 30 patients undergoing first-time atrial fibrillation ablation, 1965 stable mapping points (1409 atrial fibrillation, 556 sinus rhythm), comprising 8-s contact force (CF) and bipolar electrogram data were analyzed. Points were tak...

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Complex fractionated atrial electrograms, high dominant frequency regions, and left atrial voltages during sinus rhythm and atrial fibrillation

BACKGROUND Ablation targeting complex fractionated atrial electrograms (CFAEs) or high dominant frequency (DF) sites is generally effective for persistent atrial fibrillation (AF). CFAEs and/or high DF sites may exist in low-voltage regions, which theoretically represent abnormal substrates. However, whether CFAEs or high DF sites reflect low voltage substrates during sinus rhythm (SR) is unkno...

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ژورنال

عنوان ژورنال: Journal of Arrhythmia

سال: 2015

ISSN: 1880-4276

DOI: 10.1016/j.joa.2015.07.001